A Single Brain-Derived Neurotrophic Factor Infusion into the Dorsomedial Prefrontal Cortex Attenuates Cocaine Self-Administration-Induced Phosphorylation of Synapsin in the Nucleus Accumbens during Early Withdrawal

@inproceedings{Sun2014ASB,
  title={A Single Brain-Derived Neurotrophic Factor Infusion into the Dorsomedial Prefrontal Cortex Attenuates Cocaine Self-Administration-Induced Phosphorylation of Synapsin in the Nucleus Accumbens during Early Withdrawal},
  author={Wei-Lun Sun and Sarah A. Eisenstein and Agnieszka Zelek-Molik and Jacqueline F McGinty},
  booktitle={The international journal of neuropsychopharmacology},
  year={2014}
}
BACKGROUND Dysregulation in the prefrontal cortex-nucleus accumbens pathway has been implicated in cocaine addiction. We have previously demonstrated that one intra-dorsomedial prefrontal cortex brain-derived neurotrophic factor (BDNF) infusion immediately following the last cocaine self-administration session caused a long-lasting inhibition of cocaine-seeking and normalized the cocaine-induced disturbance of glutamate transmission in the nucleus accumbens after extinction and a cocaine prime… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Synaptic activity mediates ability of BDNF-TrkB signaling to suppress cocaine-seeking in rats

  • BS Go, JF McGinty
  • Soc Neurosci NeurOnline Planner
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…