A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*

@inproceedings{Wooldridge2012ASA,
  title={A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*},
  author={Linda Wooldridge and Julia Ekeruche-Makinde and Hugo Antonius van den Berg and Anna Skowera and John J. Miles and Mai Ping Tan and Garry Dolton and Mathew Clement and Sian Llewellyn-Lacey and David A. Price and Mark Peakman and Andrew K. Sewell},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex (MHC) molecules. Effective immunity requires that all possible foreign peptide-MHC molecules are recognized or risks leaving holes in immune coverage that pathogens could quickly evolve to exploit. It is unclear how a limited pool of <10(8) human TCRs can successfully provide immunity to the vast array of possible different… CONTINUE READING

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Quantification of this previously unappreciated high level of CD8(+ ) T cell cross - reactivity represents an important step toward understanding the system requirements for adaptive immunity and highlights the enormous potential of TCR degeneracy to be the causative factor in autoimmune disease .
Quantification of this previously unappreciated high level of CD8(+ ) T cell cross - reactivity represents an important step toward understanding the system requirements for adaptive immunity and highlights the enormous potential of TCR degeneracy to be the causative factor in autoimmune disease .
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*. The T cell receptor ( TCR ) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex ( MHC ) molecules .
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*. The T cell receptor ( TCR ) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex ( MHC ) molecules .
T-Cell ReceptorGene product expressed in tissueT-Lymphocyte
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*. The T cell receptor ( TCR ) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex ( MHC ) molecules .
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*. The T cell receptor ( TCR ) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex ( MHC ) molecules .
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*. The T cell receptor ( TCR ) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex ( MHC ) molecules .
A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*. The T cell receptor ( TCR ) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex ( MHC ) molecules .
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