A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern

@article{Hoekstra2006ASA,
  title={A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern},
  author={Hopi E. Hoekstra and Rachel J. Hirschmann and Richard A. Bundey and Paul A. Insel and Janet P. Crossland},
  journal={Science},
  year={2006},
  volume={313},
  pages={101 - 104}
}
Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor (Mc1r) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida's Gulf… 
Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes
TLDR
It is demonstrated that cryptic coloration can be based largely on a few interacting genes of major effect, including the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti).
Correction: Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes
TLDR
It is demonstrated that cryptic coloration can be based largely on a few interacting genes of major effect, including the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti).
The genetics of adaptive coat color in gophers: coding variation at Mc1r is not responsible for dorsal color differences.
TLDR
The results show that, in contrast to many other species of mammals and other vertebrates, coding variation at Mc1r is not the main determinant of coat color variation in T. bottae, and demonstrate that similar phenotypic variation may have a different genetic basis among different mammalian species.
The genetic basis of phenotypic convergence in beach mice: similar pigment patterns but different genes.
TLDR
It is shown that Atlantic coast beach mice have high levels of Mc1r polymorphism but they lack unique alleles, and convergent pigment patterns in recently diverged beach mouse subspecies have evolved through a diversity of genetic mechanisms.
Molecular and Evolutionary History of Melanism in North American Gray Wolves
TLDR
It is shown that the melanistic K locus mutation in North American wolves derives from past hybridization with domestic dogs, has risen to high frequency in forested habitats, and exhibits a molecular signature of positive selection.
An enhancer of Agouti contributes to parallel evolution of cryptically colored beach mice
TLDR
The results suggest that this newly identified Agouti enhancer allele has been maintained in mainland populations as standing genetic variation and from there has spread to, and been selected in, two independent beach mouse lineages, thereby facilitating their rapid and parallel evolution.
Natural Selection Along an Environmental Gradient: A Classic Cline in Mouse Pigmentation
  • L. Mullen, H. Hoekstra
  • Environmental Science
    Evolution; international journal of organic evolution
  • 2008
TLDR
The concordance between environmental variation and pigmentation in the face of high levels of interpopulation gene flow strongly implies that natural selection is maintaining a steep cline in pigmentation and the genes underlying it.
Adaptive Evolution of Multiple Traits Through Multiple Mutations at a Single Gene
TLDR
Using plasticine models in the field, it is shown that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators.
The Genetic Basis of a Rare Flower Color Polymorphism in Mimulus lewisii Provides Insight into the Repeatability of Evolution
TLDR
It is found that a frameshift mutation in an anthocyanin pathway gene is responsible for the white-flowered polymorphism found in this population of M. lewisii.
...
...

References

SHOWING 1-10 OF 45 REFERENCES
The genetic basis of adaptive melanism in pocket mice
TLDR
The molecular changes underlying adaptive coat color variation in a natural population of rock pocket mice, Chaetodipus intermedius, are described and four mutations in the melanocortin-1-receptor gene seem to be responsible for adaptive melanism in one population of lava-dwelling pocket mice.
Conserved Genetic Basis of a Quantitative Plumage Trait Involved in Mate Choice
TLDR
Phylogenetic reconstructions of variant MC1R alleles in geese and skuas show that melanism is a derived trait that evolved in the Pleistocene.
Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles
Major phenotypic changes evolve in parallel in nature by molecular mechanisms that are largely unknown. Here, we use positional cloning methods to identify the major chromosome locus controlling
Genetic Analysis of Coat Pattern Variation in Oldfield Mice (Peromyscus polionotus) of Western Florida
TLDR
Coat color patterns were analyzed for wild-captured oldfield mice and their laboratory-reared progeny and four major patterns of dorsal pigment distribution were recognized, together with two factors which modify these.
Adaptive coloration in Peromyscus polionotus experimental selection by owls
TLDR
Effectiveness of selection against the conspicuous prey by owls under the experimental conditions was estimated using the selection index from Dice (1947).
Pelage coloration in oldfield mice (Peromyscus polionotus) : Antipredator adaptation ?
TLDR
Regional patterns of variation in brightness of pelage provide support for the role of predation as a selective force affecting color of pelages in oldfield mice, but variation in hue and chroma and differences in crypsis did not support a selective-predation hypothesis.
...
...