A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern

@article{Hoekstra2006ASA,
  title={A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern},
  author={Hopi E. Hoekstra and Rachel J. Hirschmann and Richard A. Bundey and Paul A. Insel and Janet P. Crossland},
  journal={Science},
  year={2006},
  volume={313},
  pages={101 - 104}
}
Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor (Mc1r) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida's Gulf… 

Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes

It is demonstrated that cryptic coloration can be based largely on a few interacting genes of major effect, including the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti).

Correction: Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes

It is demonstrated that cryptic coloration can be based largely on a few interacting genes of major effect, including the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti).

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The genetic basis of phenotypic convergence in beach mice: similar pigment patterns but different genes.

It is shown that Atlantic coast beach mice have high levels of Mc1r polymorphism but they lack unique alleles, and convergent pigment patterns in recently diverged beach mouse subspecies have evolved through a diversity of genetic mechanisms.

Genetic architecture and evolution of color variation in American black bears

The cinnamon morph of American black bears and brown bears have different missense mutations in TYRP1 that account for their similar coloration, and these variants are loss-of-function alleles associated with impaired protein localization to melanosomes.

Molecular and Evolutionary History of Melanism in North American Gray Wolves

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An enhancer of Agouti contributes to parallel evolution of cryptically colored beach mice

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Natural Selection Along an Environmental Gradient: A Classic Cline in Mouse Pigmentation

  • L. MullenH. Hoekstra
  • Environmental Science
    Evolution; international journal of organic evolution
  • 2008
The concordance between environmental variation and pigmentation in the face of high levels of interpopulation gene flow strongly implies that natural selection is maintaining a steep cline in pigmentation and the genes underlying it.

Adaptive Evolution of Multiple Traits Through Multiple Mutations at a Single Gene

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The Genetic Basis of a Rare Flower Color Polymorphism in Mimulus lewisii Provides Insight into the Repeatability of Evolution

It is found that a frameshift mutation in an anthocyanin pathway gene is responsible for the white-flowered polymorphism found in this population of M. lewisii.
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