A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor ( CAR ) 1 to the Xenobiotic-Sensitive Splicing Variant CAR 3

@inproceedings{Chen2009ASA,
  title={A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor ( CAR ) 1 to the Xenobiotic-Sensitive Splicing Variant CAR 3},
  author={Tao Chen and Leslie Meredith Tompkins and Linhao Li and Haishan Li and Gregory G. Kim and Yuxin Zheng and Hongbing Wang},
  year={2009}
}
The constitutive androstane receptor (CAR) is constitutively activated in immortalized cell lines independent of xenobiotic stimuli. This feature of CAR has limited its use as a sensor for xenobiotic-induced expression of drug-metabolizing enzymes. Recent reports, however, reveal that a splicing variant of human CAR (hCAR3), which contains an insertion of five amino acids (APYLT), exhibits low basal but xenobiotic-inducible activities in cell-based reporter assays. Nonetheless, the underlying… CONTINUE READING

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