A Single Amino Acid Alteration in Cytoplasmic Domain Determines IL-2 Promoter Activation by Ligation of CD28 but Not Inducible Costimulator (ICOS)

@article{Harada2003ASA,
  title={A Single Amino Acid Alteration in Cytoplasmic Domain Determines IL-2 Promoter Activation by Ligation of CD28 but Not Inducible Costimulator (ICOS)},
  author={Yohsuke Harada and Daisuke Ohgai and Ryosuke Watanabe and Kazuhiro Okano and Osamu Koiwai and Kazunari Tanabe and Hiroshi Toma and Amnon Altman and Ryo Abe},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={257 - 262}
}
The CD28 family molecules, CD28, and inducible costimulator (ICOS) all provide positive costimulatory signals. However, unlike CD28, ICOS does not costimulate IL-2 secretion. The YMNM motif that exists in the CD28 cytoplasmic domain is a known binding site for phosphatidylinositol 3-kinase (PI3-K) and Grb2. ICOS possesses the YMFM motif in the corresponding region of CD28 that binds PI3-K but not Grb2. We postulated that the reason that ICOS does not have the ability to induce IL-2 production… CONTINUE READING

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