A Single‐Dose, Two‐Way Crossover, Bioequivalence Study of Dexmethylphenidate HCl with and without Food in Healthy Subjects

@article{Teo2004AST,
  title={A Single‐Dose, Two‐Way Crossover, Bioequivalence Study of Dexmethylphenidate HCl with and without Food in Healthy Subjects},
  author={S. Teo and M. R. Scheffler and A. Wu and D. Stirling and S. Thomas and D. Stypinski and V. Khetani},
  journal={The Journal of Clinical Pharmacology},
  year={2004},
  volume={44}
}
Attention deficit hyperactivity disorder (ADHD) in children is effectively treated by racemic oral methylphenidate (dl‐MPH). The d‐isomer (d‐MPH) has been developed as an improved treatment for ADHD since only half the racemic dose is used. This study, performed in healthy subjects, assessed the effect of food on the pharmacokinetics of dexmethylphenidate hydrochloride (d‐MPH HCl) in a single dose (2 × 10‐mg tablets), two‐way crossover with d‐MPH administered to subjects in both a fasting state… Expand
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