A Simple and Efficient Preparation of Penicillin V β-Sulfoxide

@inproceedings{Davis1986ASA,
  title={A Simple and Efficient Preparation of Penicillin V β-Sulfoxide},
  author={Michael Davis and W.-Y. Wu},
  year={1986}
}
Penicillin V (1) can be oxidized to the β- sulfoxide (2) in high yield in a two-phase mixture of dichloromethane and aqueous hydrogen peroxide. The addition of acids or metallic catalysts is not necessary.