A Simple and Broadly Applicable C-N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents.

Abstract

A C-N bond forming dearomatization protocol with broad scope is outlined. Specifically, bifunctional amino reagents are used for sequential nucleophilic and electrophilic C-N bond formations, with the latter effecting the key dearomatization step. Using this approach, γ-arylated alcohols are converted to a wide range of differentially protected spirocyclic pyrrolidines in just two or three steps.

DOI: 10.1002/anie.201708176

Cite this paper

@article{Ma2017ASA, title={A Simple and Broadly Applicable C-N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents.}, author={Xiaofeng Ma and Joshua J Farndon and Tom A Young and Natalie Fey and John F Bower}, journal={Angewandte Chemie}, year={2017}, volume={56 46}, pages={14531-14535} }