A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B

@inproceedings{BecerraArtiles2015ASP,
  title={A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B},
  author={Aniuska Becerra-Artiles and Omar Dominguez-Amorocho and Lawrence J Stern and Jaime Mauricio Calvo-Calle and Scheherazade Sadegh-Nasseri},
  booktitle={PloS one},
  year={2015}
}
Most of humanity is chronically infected with human herpesvirus 6 (HHV-6), with viral replication controlled at least in part by a poorly characterized CD4 T cell response. Identification of viral epitopes recognized by CD4 T cells is complicated by the large size of the herpesvirus genome and a low frequency of circulating T cells responding to the virus. Here, we present an alternative to classical epitope mapping approaches used to identify major targets of the T cell response to a complex… CONTINUE READING

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A Simple Proteomics - Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen : Application to the CD4 T Cell Response against Human Herpesvirus 6B. Most of humanity is chronically infected with human herpesvirus 6 ( HHV-6 ) , with viral replication controlled at least in part by a poorly characterized CD4 T cell response .
A Simple Proteomics - Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen : Application to the CD4 T Cell Response against Human Herpesvirus 6B. Most of humanity is chronically infected with human herpesvirus 6 ( HHV-6 ) , with viral replication controlled at least in part by a poorly characterized CD4 T cell response .
A Simple Proteomics - Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen : Application to the CD4 T Cell Response against Human Herpesvirus 6B. Most of humanity is chronically infected with human herpesvirus 6 ( HHV-6 ) , with viral replication controlled at least in part by a poorly characterized CD4 T cell response .
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