A Simple Process for the Experimental Induction of Resistance in Schistosoma mansoni to Antishistosomal Agents

  title={A Simple Process for the Experimental Induction of Resistance in Schistosoma mansoni to Antishistosomal Agents},
  author={P. Lar and J. Oyerinde},
  journal={Research Journal of Parasitology},
This study was carried out to identify the easiest process of inducing drug resistance in the parent generation of S. mansoni in mice_after subjecting them to drug pressure. Adult albino mice were infected with S. mansoni cercariae and were given various subcurative doses of niridazole orally at 2 weeks, 4 weeks and 8 weeks (that is 14, 28 and 56 days) post-cercarial infection followed by the curative dose of niridazole for (250 mg kg:' body weight for 5 days). We found that the adult worms (8… Expand
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