A Simple Method for Preparation of 18α-Glycyrrhetinic Acid and Its Derivatives

@article{Ignatov2004ASM,
  title={A Simple Method for Preparation of 18α-Glycyrrhetinic Acid and Its Derivatives},
  author={D. V. Ignatov and Yu. I. Prokof'ev and Olga M. Ipatova and Vladimir P. Timofeev and N. V. Medvedeva and A. Yu. Misharin},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2004},
  volume={29},
  pages={390-394}
}
Treatment of 18β-glycyrrhizic acid with a methanolic solution of HCl resulted in 1 : 1 mixture of methyl esters of 18α- and 18β-glycyrrhetinic acids. Benzoylation of the mixture led to methyl esters of 3-benzoyl-18α-glycyrrhetinic acid and 3-benzoyl-18β-glycyrrhetinic acid, which were separated by chromatography on silica gel. 18α-Glycyrrhetinic acid was prepared by alkaline hydrolysis of methyl 3-benzoyl-18α-glycyrrhetinate and was further used for the syntheses of 3-keto-18α-glycyrrhetinic… CONTINUE READING

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Translated under the title Reagenty dlya organicheskogo sinteza, Moscow: Mir

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