A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy.

@article{Hu2017ASH,
  title={A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy.},
  author={Li-jun Hu and Xiao-fang Li and Jin-Qing Hu and Xiao-Jia Ni and Hao-Yang Lu and Jun-hua Wang and Xiang-ning Huang and Chao-Xian Lin and De-wei Shang and Yu-guan Wen},
  journal={Journal of analytical toxicology},
  year={2017},
  volume={41 1},
  pages={37-44}
}
The kynurenine pathway, in which tryptophan is metabolized to kynurenine and kynurenic acid, has been linked to depression. A rapid and highly reproducible liquid-chromatography-tandem mass spectrometry (LC-MS/MS) method were established for determining tryptophan, kynurenine and kynurenic acid in human serum. Biological samples were precipitated with… CONTINUE READING