A Short History Of Nitroglycerine And Nitric Oxide In Pharmacology And Physiology

@article{Marsh2000ASH,
  title={A Short History Of Nitroglycerine And Nitric Oxide In Pharmacology And Physiology},
  author={N. Marsh and A. Marsh},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2000},
  volume={27}
}
  • N. Marsh, A. Marsh
  • Published 2000
  • Medicine
  • Clinical and Experimental Pharmacology and Physiology
1. Nitroglycerine (NG) was discovered in 1847 by Ascanio Sobrero in Turin, following work with Theophile‐Jules Pelouze. Sobrero first noted the ‘violent headache’ produced by minute quantities of NG on the tongue. 
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References

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  • W. Murrell
  • Medicine, Chemistry
  • Glasgow Medical Journal
  • 1882
It is only quite recently that nitro-glycerine has been much recommended in cases in which the nitrite of amyl had been found to be of service, the physiological effects of the two drugs being veryExpand
Nitroglycerin: a homeopathic remedy.
La nitroglycerine, initialement un remede homeopathique, en plus de son role important dans le traitement des patients atteints d'une cardiopathie ischemique, a aussi indirectement conduit aExpand
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TLDR
Men working in powder plants soon acquire a rather transient immunity to nitroglycerin that can rapidly be lost over a period such as a weekend or during a vacation, which results in a severe headache, which is also experienced by men first. Expand
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1. Nitric oxide (NO) is released from vascular endothelium following conversion of l‐arginine to l‐citrulline by calcium‐calmodulin‐dependent ‘constitutive’ NO‐synthase.
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The vasodilator effects of histamine and Mautner and Pick's theory are applied as follows: local application of histamines, immediate effects of nerve section, and effects of prolonged anaemia and cooling. Expand
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TLDR
Nitric oxide was initially characterized as the "endothelium-derived relaxation factor" and subsequently found to mediate the elevation in cGMP following glutamatergic stimulation in the nervous system. Expand
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TLDR
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The aim of the present research was to determine as far as possible the exact action of digitalis and vaso-dilators in combination as recommended by Huchard', and as these are the substances mainly used for this purpose an accurate knowledge of the question is of importance. Expand
Biological Actions and Properties of Endothelium-Derived Nitric Oxide Formed and Released From Artery and Vein
TLDR
Article de synthese traitant de la pharmacologie de l'oxyde nitrique, du facteur EDRF and du GMP cyclique dans les vaisseaux sanguins and les thrombocytes, de la formation, de the liberation and du metabolisme de l’endothelium derived NO (EDNO). Expand
Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP.
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A direct relation between cAMP, relaxation, and phosphorylase can be reconciled with the antiparallel effects of alterations of eicosonoid metabolism observed in this study by a proposed model in which the effects of cAMP are assumed to be functionally compartmentalized. Expand
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