A Shared Vesicular Carrier Allows Synaptic Corelease of GABA and Glycine

Abstract

The type of vesicular transporter expressed by a neuron is thought to determine its neurotransmitter phenotype. We show that inactivation of the vesicular inhibitory amino acid transporter (Viaat, VGAT) leads to embryonic lethality, an abdominal defect known as omphalocele, and a cleft palate. Loss of Viaat causes a drastic reduction of neurotransmitter… (More)
DOI: 10.1016/j.neuron.2006.04.016

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