A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

@article{Yadav2009ASM,
  title={A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure},
  author={Vijay K Yadav and Franck Oury and Nina Suda and Zhong-wu Liu and X B Gao and Cyrille B Confavreux and Kristen C. Klemenhagen and Kenji F Tanaka and Jay A Gingrich and Xiangdong Edward Guo and Laurence H. Tecott and John. J. Mann and Ren{\'e} Hen and Tam{\'a}s L. Horv{\'a}th and Gerard Karsenty},
  journal={Cell},
  year={2009},
  volume={138},
  pages={976-989}
}
Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on these neurons. The same is true for its regulation of appetite and energy expenditure. This suggests that leptin acts elsewhere in the brain to achieve these three functions. We show here that brainstem-derived serotonin (BDS) favors bone mass accrual following its binding to Htr2c receptors on ventromedial hypothalamic neurons and appetite via Htr1a and 2b… CONTINUE READING
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