A Sequential Significance Test for Treatment by Covariate Interactions

@article{Qian2021ASS,
  title={A Sequential Significance Test for Treatment by Covariate Interactions},
  author={Min Qian and Bibhas Chakraborty and Raju Maiti and Ying Kuen Cheung},
  journal={Statistica Sinica},
  year={2021}
}
Due to patient heterogeneity in response to various aspects of any treatment program, biomedical and clinical research is gradually shifting from the traditional "one-size-fits-all" approach to the new paradigm of personalized medicine. An important step in this direction is to identify the treatment by covariate interactions. We consider the setting in which there are potentially a large number of covariates of interest. Although a number of novel machine learning methodologies have been… 

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