A Sequence Motif within Chromatin Entry Sites Directs MSL Establishment on the Drosophila X Chromosome

@article{Alekseyenko2008ASM,
  title={A Sequence Motif within Chromatin Entry Sites Directs MSL Establishment on the Drosophila X Chromosome},
  author={Artyom A. Alekseyenko and Shouyong Peng and Erica Larschan and Andrey A. Gorchakov and Ok-Kyung Lee and Peter V. Kharchenko and Sean D. McGrath and Charlotte I-Wen Wang and Elaine R. Mardis and Peter J. Park and Mitzi I. Kuroda},
  journal={Cell},
  year={2008},
  volume={134},
  pages={599-609}
}
The Drosophila MSL complex associates with active genes specifically on the male X chromosome to acetylate histone H4 at lysine 16 and increase expression approximately 2-fold. To date, no DNA sequence has been discovered to explain the specificity of MSL binding. We hypothesized that sequence-specific targeting occurs at "chromatin entry sites," but the majority of sites are sequence independent. Here we characterize 150 potential entry sites by ChIP-chip and ChIP-seq and discover a GA-rich… CONTINUE READING
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