A Sensitive A Oligomerization Assay for Identification of Small Molecule Inhibitors

@inproceedings{Gonzales2009ASA,
  title={A Sensitive A Oligomerization Assay for Identification of Small Molecule Inhibitors},
  author={Amanda M. Gonzales and Robert A. Orlando},
  year={2009}
}
Amyloid deposits found in Alzheimer’s disease result from aggregation of peptide which leads to loss of synaptic function, chronic microglial activation and cognitive impairment. Because of this, identification of small molecule inhibitors of aggregation as potential therapeutics is a topic of current interest. The majority of inhibitor screening approaches rely on in vitro assays that lack the necessary sensitivity to distinguish low-molecular weight oligomers from larger, more advanced-stage… CONTINUE READING