A Sensitive, Validated Gas‐chromatographic Bioanalytical Method by Nitrogen Selective Detection of Deramciclane in Dog Plasma

@article{Klebovich1997ASV,
  title={A Sensitive, Validated Gas‐chromatographic Bioanalytical Method by Nitrogen Selective Detection of Deramciclane in Dog Plasma},
  author={Imre Klebovich and J{\'a}nos Leibinger and Miklos Abermann and Gy. Gr{\'e}zal},
  journal={Pharmacy and Pharmacology Communications},
  year={1997},
  volume={3},
  pages={497-501}
}
A validated bioanalytical method has been developed for the determination of a new anxiolytic compound of deramciclane in dog plasma, using Lichrolut RP-18 solid-phase extraction and gas chromatography with nitrogen-phosphorous selective detector (GC-NPD). Gas-chromatographic separation was carried out by SPB-5 fused silica capillary column (30 m × 0·25 mm × 0·25 μm) after split injection, when the split liner was packed (3% silicone SE 30). An optimized two-level oven temperature… Expand
1 Citations
Biopharmaceutics: Different Absorption Profiles of Deramciclane in Man and in Dog
TLDR
The dog model for predicting the oral absorption of deramciclane, a novel anxiolytic compound, as a model acid‐labile drug, is studied in man and beagle dogs after administration of conventional capsules and enteric coated tablets. Expand