A Semi-mechanistic Modeling Strategy for Characterization of Regional Absorption Properties and Prospective Prediction of Plasma Concentrations Following Administration of New Modified Release Formulations

@article{Bergstrand2011ASM,
  title={A Semi-mechanistic Modeling Strategy for Characterization of Regional Absorption Properties and Prospective Prediction of Plasma Concentrations Following Administration of New Modified Release Formulations},
  author={Martin Bergstrand and Erik S{\"o}derlind and Ulf G. Eriksson and Werner Weitschies and Mats O. Karlsson},
  journal={Pharmaceutical Research},
  year={2011},
  volume={29},
  pages={574-584}
}
To outline and test a new modeling approach for prospective predictions of absorption from newly developed modified release formulations based on in vivo studies of gastro intestinal (GI) transit, drug release and regional absorption for the investigational drug AZD0837. This work was a natural extension to the companion article “A semi-mechanistic model to link in vitro and in vivo drug release for modified release formulations”. The drug release model governed the amount of substance released… CONTINUE READING