A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization

@inproceedings{Toledano2016ASM,
  title={A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization},
  author={Shira Toledano and Huayi Lu and Agustina Palacio and K. Ziv and Ofra Kessler and Shlomit Schaal and Gera Neufeld and Yoreh Barak},
  booktitle={PloS one},
  year={2016}
}
In age-related macular degeneration (AMD), abnormal sub retinal choroidal neovascularization (CNV) is a major cause of blindness. FR-sema3C is a point mutated form of semaphorin-3C that is resistant to cleavage by furin like pro-protein convertases (FPPC). We have found in previous work that FR-sema3C functions as an anti-angiogenic factor. In this study we investigated the possible use of FR-sema3C as an inhibitor of CNV. FR-sema3C inhibits VEGF as well as PDGF-BB signal transduction in… CONTINUE READING

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SHOWING 1-10 OF 61 REFERENCES

Neuropilin regulation of angiogenesis.

Ocular neovascularization