A Secreted Protein Promotes Cleavage Furrow Maturation during Cytokinesis

@article{Xu2011ASP,
  title={A Secreted Protein Promotes Cleavage Furrow Maturation during Cytokinesis},
  author={Xuehong Xu and Bruce E. Vogel},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={114-119}
}
Developmental modifications in cell shape depend on dynamic interactions between the extracellular matrix and cytoskeleton. In contrast, existing models of cytokinesis describe substantial cell surface remodeling that involves many intracellular regulatory and structural proteins but includes no contribution from the extracellular matrix [1-3]. Here, we show that extracellular hemicentins assemble at the cleavage furrow of dividing cells in the C. elegans germline and in preimplantation mouse… CONTINUE READING
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