A Secreted Form of the Asialoglycoprotein Receptor, sH2a, as a Novel Potential Noninvasive Marker for Liver Fibrosis

@inproceedings{Veselkin2011ASF,
  title={A Secreted Form of the Asialoglycoprotein Receptor, sH2a, as a Novel Potential Noninvasive Marker for Liver Fibrosis},
  author={Elena Veselkin and Maria K. Kondratyev and Yoav Lurie and Efrat Ron and M J Del Santo and Shimon Reif and Irma Elashvili and Lana Bar and Gerardo Zelmar Lederkremer},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND AND AIM The human asialoglycoprotein receptor is a membrane heterooligomer expressed exclusively in hepatocytes. A soluble secreted form, sH2a, arises, not by shedding at the cell surface, but by intracellular cleavage of its membrane-bound precursor, which is encoded by an alternatively spliced form of the receptor H2 subunit. Here we determined and report that sH2a, present at constant levels in serum from healthy individuals is altered upon liver fibrosis, reflecting the status of… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.

Targeted therapy against hepatocellular carcinoma

Songlin Chen, Lei Yang, +6 authors Yinghui Lin
  • 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Assessing fibrosis without a liver biopsy: are we there yet?

  • Gastroenterology
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL