A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis

@inproceedings{Newton2014ASO,
  title={A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis},
  author={Hayley J Newton and Lara J. Kohler and Justin A. McDonough and Morayma M Temoche-Diaz and Emerson Crabill and Elizabeth L Hartland and Craig R Roy},
  booktitle={PLoS pathogens},
  year={2014}
}
Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole remain largely unknown. Here, we conducted a visual screen on an arrayed library of C. burnetii NMII transposon insertion mutants to identify genes required for biogenesis of a mature Coxiella-containing vacuole (CCV). Mutants defective in Dot/Icm secretion system function or the PmrAB regulatory system were incapable… CONTINUE READING
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