A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion

@article{Fu1999ASP,
  title={A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion},
  author={Yixin Fu and Jorge E. Gal{\'a}n},
  journal={Nature},
  year={1999},
  volume={401},
  pages={293-297}
}
An essential feature of the bacterial pathogen Salmonella spp. is its ability to enter cells that are normally non-phagocytic, such as those of the intestinal epithelium. The bacterium achieves entry by delivering effector proteins into the host-cell cytosol by means of a specialized protein-secretion system (termed type III), which causes reorganization of the cell's actin cytoskeleton and ruffling of its membrane. One of the bacterial effectors that stimulates these cellular responses is SopE… CONTINUE READING
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Role of the S . Typhimurium actin - binding protein SipA in bacterial internalization

  • D. Zhou, M. Mooseker, J. E. GalaÂn
  • Science
  • 1999

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