A Salmonella enterica serovar typhimurium hemA mutant is highly susceptible to oxidative DNA damage.

@article{ElgrablyWeiss2002ASE,
  title={A Salmonella enterica serovar typhimurium hemA mutant is highly susceptible to oxidative DNA damage.},
  author={M. Elgrably-Weiss and Sunny Park and E. Schlosser-Silverman and I. Rosenshine and J. Imlay and S. Altuvia},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 14},
  pages={
          3774-84
        }
}
The first committed step in the biosynthesis of heme, an important cofactor of two catalases and a number of cytochromes, is catalyzed by the hemA gene product. Salmonella enterica serovar Typhimurium hemA26::Tn10d (hemA26) was identified in a genetic screen of insertion mutants that were sensitive to hydrogen peroxide. Here we show that the hemA26 mutant respires at half the rate of wild-type cells and is highly susceptible to the effects of oxygen species. Exposure of the hemA26 strain to… Expand
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