A Salmonella enterica serovar typhimurium hemA mutant is highly susceptible to oxidative DNA damage.

@article{ElgrablyWeiss2002ASE,
  title={A Salmonella enterica serovar typhimurium hemA mutant is highly susceptible to oxidative DNA damage.},
  author={M. Elgrably-Weiss and Sunny Park and E. Schlosser-Silverman and I. Rosenshine and J. Imlay and S. Altuvia},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 14},
  pages={
          3774-84
        }
}
The first committed step in the biosynthesis of heme, an important cofactor of two catalases and a number of cytochromes, is catalyzed by the hemA gene product. Salmonella enterica serovar Typhimurium hemA26::Tn10d (hemA26) was identified in a genetic screen of insertion mutants that were sensitive to hydrogen peroxide. Here we show that the hemA26 mutant respires at half the rate of wild-type cells and is highly susceptible to the effects of oxygen species. Exposure of the hemA26 strain to… Expand
38 Citations
Fusidic Acid-Resistant Mutants of Salmonella enterica Serovar Typhimurium Have Low Levels of Heme and a Reduced Rate of Respiration and Are Sensitive to Oxidative Stress
  • 20
  • Highly Influenced
  • PDF
Salmonella detoxifying enzymes are sufficient to cope with the host oxidative burst
  • 91
A mechanism by which nitric oxide accelerates the rate of oxidative DNA damage in Escherichia coli
  • 63
KatG is the primary detoxifier of hydrogen peroxide produced by aerobic metabolism in Bradyrhizobium japonicum.
  • 51
  • Highly Influenced
  • PDF
Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium.
...
1
2
3
4
...

References

SHOWING 1-10 OF 46 REFERENCES
Conditional stability of the HemA protein (glutamyl-tRNA reductase) regulates heme biosynthesis in Salmonella typhimurium.
  • 96
  • PDF
Cloning, genetic characterization, and nucleotide sequence of the hemA-prfA operon of Salmonella typhimurium.
  • T. Elliott
  • Biology, Medicine
  • Journal of bacteriology
  • 1989
  • 74
  • PDF
OxyR and SoxRS regulation of fur.
  • 393
  • PDF
Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide.
  • 326
  • PDF
A mutant HemA protein with positive charge close to the N terminus is stabilized against heme-regulated proteolysis in Salmonella typhimurium.
  • 61
  • PDF
HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination
  • 109
  • PDF
...
1
2
3
4
5
...