A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats

  title={A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats},
  author={A. Abolaji and Mbeh Ubana Eteng and Patrick Ekong Ebong and Ebiamadon Andi Brisibe and Ahsana Dar and Nurul Kabir and Mohammad Iqbal Choudhary},
  journal={Phytotherapy Research},
Artemisia annua is a Chinese antimalarial herb that has been used for more than 2000 years. [] Key Method Twenty pregnant rats, divided into four study groups of saline treated (control), and test groups administered orally with 100, 200 and 300 mg/kg body weights of EAA, respectively, from gestation days (GD) 8 to 19. Following overnight fast, animals were sacrificed on GD 20, and maternal blood was collected to evaluate biochemical and haematological markers.

Artemisia annua as a possible contraceptive agent: a clue from mammalian rat model

The results showed that A. annua significantly reduced litter size, reproductive outcome and fertility indices compared with the control, implying that the herb could serve as a prospective contraceptive agent in addition to its antimalarial activity.

Protective effects of some Nigerian indigenous antimalarial plants on placental malaria related pathological damages and pregnancy outcomes in murine model

The use of herbs was significantly associated with poor pregnancy outcomes (pups weight, pups mortality, and litter size) in this study and this study found that malaria related pathological damages were more pronounced in placenta of mice treated with C. citatrus.

Tumor suppressive effect of Artemisia annua extract in 7, 12-dimethylbenz[a] anthracene-induced breast cancer in Wistar rats

The use of A. annua extract is recommended as a promising complementary drug in breast cancer treatment after detecting the genetic and immunohistochemical effects of the extract of Artemisia annua in a chemical model of breast cancer.

Cultivation, phytochemical and in vitro anti-plasmodium activity of Artemisia annua L. (Asteraceae)

The chemical synthesis of Artemisinin for the production of Artemisinin-based Combination Therapies (ACTs) is complex, uneconomical and produces low yields, thus, the main source of Artemisinin is

Teratogen update: Malaria in pregnancy and the use of antimalarial drugs in the first trimester

  • R. Clark
  • Medicine, Biology
    Birth defects research
  • 2020
Limitations in the assessment of the safety of ACTs in the first trimester are a lack of exposures early in gestation, limited postnatal evaluation for cardiovascular malformations, and the pooling of all ACTs for the Assessment of risk.

Developmental, Behavioral And Reproductive Consequences In Female Progeny Exposed To Artemisia Annua L Leaf Extract In Utero

In utero exposure to AAL compromised postnatal developments and fertility efficiency in female progeny, and Behavioral observations such as cliff avoidance, negative geotaxis, surface rightening activity, and ascending wire mesh were impaired in experimental pups.

Antiplasmodial activities and abortifacient properties of three commonly used African indigenous anti-malarial plants in Plasmodium berghei infected pregnant mice: implication for maternal and fetal health

This study showed that M. lucida and E. chlorantha had anti-malarial properties, which are promising in reducing problems with pregnancy associated malaria in the face of growing resistance to currently available drugs, however, they are capable of inducing abortion by impairing the production of progesterone.

Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents

The most recent evidence on health effects of edible Artemisia species and some of its constituents are presented and discussed, based on studies published until 2020, related to food applications, nutritional and sesquiterpene lactones composition, and their therapeutic effects supported by in vivo and clinical studies.



Toxicity of artemisinin [Artemisia annua L.] in two different periods of pregnancy in Wistar rats.

Developmental and reproductive toxicity studies on artemisone.

Artemisone was shown to be embryo- and fetotoxic and induced cardiac ventricular septal defects and retarded ossification in dosages where total litter loss and abortions were observed, however, no effect on reproductive and developmental parameters below severe toxic dosages could be observed.

Phytochemical analysis of a herbal tea from Artemisia annua L.

Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood).

Artemisia annua L. (annual wormwood) contains the antimalarial artemisinin, and plasma concentrations after intake of this herbal tea are sufficient for clinical effects, but insufficient to recommend such preparations as equivalent substitutes for modern art Artemisinin drugs in malaria therapy.

Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro.

Qinghaosu (artemisinin): an antimalarial drug from China

Derivatives of QHS, such as dihydroqinghaosu, artemether, and the water-soluble sodium artesunate, appear to be more potent than QHS itself, and offer promise as a totally new class of antimalarials.

Severe Embryotoxicity of Artemisinin Derivatives in Experimental Animals, but Possibly Safe in Pregnant Women

Evidence was presented that the mechanism by which embryotoxicity of artemisinins occurs seems to be limited to fetal erythropoiesis and vasculogenesis/ angiogenesis on the very earliest developing red blood cells, causing severe anemia in the embryos with higher drug peak concentrations.