A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats

@article{Abolaji2013ASA,
  title={A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats},
  author={A. Abolaji and Mbeh Ubana Eteng and Patrick Ekong Ebong and Ebiamadon Andi Brisibe and Ahsana Dar and Nurul Kabir and Mohammad Iqbal Choudhary},
  journal={Phytotherapy Research},
  year={2013},
  volume={27}
}
Artemisia annua is a Chinese antimalarial herb that has been used for more than 2000 years. [...] Key Method Twenty pregnant rats, divided into four study groups of saline treated (control), and test groups administered orally with 100, 200 and 300 mg/kg body weights of EAA, respectively, from gestation days (GD) 8 to 19. Following overnight fast, animals were sacrificed on GD 20, and maternal blood was collected to evaluate biochemical and haematological markers.Expand
Artemisia annua as a possible contraceptive agent: a clue from mammalian rat model
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The use of herbs was significantly associated with poor pregnancy outcomes (pups weight, pups mortality, and litter size) in this study and this study found that malaria related pathological damages were more pronounced in placenta of mice treated with C. citatrus. Expand
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It is demonstrated that oral administration of artemisinin can adversely effect post-implantation development and pregnancy in the rat, with toxicity for both periods of treatment. Expand
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It is proposed that a traditional aqueous preparation from Artemisia annua, with a low content of the active compound, artemisinin, may reduce the risk of resistance of the protozoa and be relatively more effective in the treatment of the disease. Expand
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Evidence was presented that the mechanism by which embryotoxicity of artemisinins occurs seems to be limited to fetal erythropoiesis and vasculogenesis/ angiogenesis on the very earliest developing red blood cells, causing severe anemia in the embryos with higher drug peak concentrations. Expand
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