A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1

@inproceedings{Westerbeck2014ASU,
  title={A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1},
  author={Jason W. Westerbeck and Nagesh Pasupala and Mark L Guillotte and Eva Paige Szymanski and Brooke C. Matson and Cecilia Esteban and Oliver Kerscher},
  booktitle={Molecular biology of the cell},
  year={2014}
}
The Slx5/Slx8 heterodimer constitutes a SUMO-targeted ubiquitin ligase (STUbL) with an important role in SUMO-targeted degradation and SUMO-dependent signaling. This STUbL relies on SUMO-interacting motifs in Slx5 to aid in substrate targeting and carboxy-terminal RING domains in both Slx5 and Slx8 for substrate ubiquitylation. In budding yeast cells, Slx5 resides in the nucleus, forms distinct foci, and can associate with double-stranded DNA breaks. However, it remains unclear how STUbLs… CONTINUE READING
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