A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae.

Abstract

The ESC2 gene encodes a protein with two tandem C-terminal SUMO-like domains and is conserved from yeasts to humans. Previous studies have implicated Esc2 in gene silencing. Here, we explore the functional significance of SUMO-like domains and describe a novel role for Esc2 in promoting genome integrity during DNA replication. This study shows that… (More)
DOI: 10.1534/genetics.107.086249

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@article{Ohya2008ASD, title={A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae.}, author={Tomoko Ohya and Hirokazu Arai and Yoshino Kubota and Hideo Shinagawa and Takashi Hishida}, journal={Genetics}, year={2008}, volume={180 1}, pages={41-50} }