A STUDY ON CLAVULANIC ACID PRODUCTION BY Streptomyces clavuligerus IN BATCH, FED-BATCH AND CONTINUOUS PROCESSES

Abstract

Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was… (More)

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