A STIM2 splice variant negatively regulates store-operated calcium entry

@inproceedings{Miederer2015ASS,
  title={A STIM2 splice variant negatively regulates store-operated calcium entry},
  author={Anna-Maria Miederer and Dalia Alansary and Gertrud Schw{\"a}r and Po-Hsien Lee and Martin Jung and Volkhard Helms and Barbara A Niemeyer},
  booktitle={Nature communications},
  year={2015}
}
Cellular homeostasis relies upon precise regulation of Ca(2+) concentration. Stromal interaction molecule (STIM) proteins regulate store-operated calcium entry (SOCE) by sensing Ca(2+) concentration in the ER and forming oligomers to trigger Ca(2+) entry through plasma membrane-localized Orai1 channels. Here we characterize a STIM2 splice variant, STIM2.1, which retains an additional exon within the region encoding the channel-activating domain. Expression of STIM2.1 is ubiquitous but its… CONTINUE READING
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