A STEP forward in neural function and degeneration.

@article{Baum2010ASF,
  title={A STEP forward in neural function and degeneration.},
  author={Matthew L. Baum and Pradeep K. Kurup and Juan Xu and Paul J. Lombroso},
  journal={Communicative & integrative biology},
  year={2010},
  volume={3 5},
  pages={
          419-22
        }
}
STriatal-Enriched Phosphatase (STEP) is a brain-specific protein tyrosine phosphatase that plays a role in synaptic plasticity and has recently been implicated in neurodegenerative disease. STEP opposes the development of synaptic strengthening by dephosphorylating and inactivating key signaling proteins that include the MAP kinases ERK1/2 and p38, as well as the tyrosine kinase Fyn. STEP also dephosphorylates the GluR2 subunit of the AMPAR and the NR2B subunit of the NMDAR, which leads to… CONTINUE READING
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