A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.

@article{Gschweitl2016ASU,
  title={A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes.},
  author={Michaela Gschweitl and Anna Ulbricht and Christopher A. Barnes and Radoslav Ivanov Enchev and Ingrid Stoffel-Studer and Nathalie Meyer-Schaller and Jatta Huotari and Yohei Yamauchi and Urs F. Greber and Ari Helenius and Matthias Peter},
  journal={eLife},
  year={2016},
  volume={5},
  pages={e13841}
}
Cullin-3 (CUL3)-based ubiquitin ligases regulate endosome maturation and trafficking of endocytic cargo to lysosomes in mammalian cells. Here, we report that these functions depend on SPOPL, a substrate-specific CUL3 adaptor. We find that SPOPL associates with endosomes and is required for both the formation of multivesicular bodies (MVBs) and the endocytic host cell entry of influenza A virus. In SPOPL-depleted cells, endosomes are enlarged and fail to acquire intraluminal vesicles (ILVs). We… CONTINUE READING
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