A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions

@article{Hakenberg2012ASO,
  title={A SNPshot of PubMed to associate genetic variants with drugs, diseases, and adverse reactions},
  author={J{\"o}rg Hakenberg and Dmitry Voronov and Nguyen Ha Vo and Shanshan Liang and Saadat Anwar and Barry Lumpkin and Robert Leaman and Luis Tari and Chitta Baral},
  journal={Journal of biomedical informatics},
  year={2012},
  volume={45 5},
  pages={842-50}
}
MOTIVATION Genetic factors determine differences in pharmacokinetics, drug efficacy, and drug responses between individuals and sub-populations. Wrong dosages of drugs can lead to severe adverse drug reactions in individuals whose drug metabolism drastically differs from the "assumed average". Databases such as PharmGKB are excellent sources of pharmacogenetic information on enzymes, genetic variants, and drug response affected by changes in enzymatic activity. Here, we seek to aid researchers… CONTINUE READING
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