A SNP in the ABCC11 gene is the determinant of human earwax type

@article{Yoshiura2006ASI,
  title={A SNP in the ABCC11 gene is the determinant of human earwax type},
  author={Koh-ichiro Yoshiura and Akira Kinoshita and Takafumi Ishida and Aya Ninokata and Toshihisa Ishikawa and Tadashi Kaname and Makoto Bannai and Katsushi Tokunaga and Shunro Sonoda and Ryoichi Komaki and Makoto Ihara and Vladimir A Saenko and Gabit K. Alipov and Ichiro Sekine and Kazuki Komatsu and Haruo Takahashi and Mitsuko Nakashima and Nadiya Sosonkina and Christophe K. Mapendano and Mohsen Ghadami and Masayo Nomura and De-sheng Liang and Nobutomo Miwa and Dae-Kwang Kim and Ariuntuul Garidkhuu and Nagato Natsume and Tohru Ohta and Hiroaki Tomita and Akira Kaneko and Mihoko Kikuchi and Graciela Russomando and Kenji Hirayama and Minaka Ishibashi and Aya Takahashi and Naruya Saitou and Jeffery C Murray and Susumu Saito and Yusuke Nakamura and Norio Niikawa},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={324-330}
}
Human earwax consists of wet and dry types. Dry earwax is frequent in East Asians, whereas wet earwax is common in other populations. Here we show that a SNP, 538G → A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. The AA genotype corresponds to dry earwax, and GA and GG to wet type. A 27-bp deletion in ABCC11 exon 29 was also found in a few individuals of Asian ancestry. A functional assay demonstrated that cells with allele A show a lower excretory activity… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

Ethnic/Racial and Genetic Influences on Cerumen Odorant Profiles

Journal of Chemical Ecology • 2014
View 5 Excerpts
Highly Influenced

The impact of natural selection on an ABCC11 SNP determining earwax type.

Molecular biology and evolution • 2011
View 6 Excerpts
Highly Influenced

Genetic Determinants of Nipple Aspiration Fluid Yield

Annals of Surgical Oncology • 2016
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 34 references

New strategies in pharmacogenomics

Ishikawa, T. et al. High-speed screening of human ABC transport function, genetic polymorphisms
Methods Enzymol. 400, 485–510 • 2005

direct evidence from three cases of confined placental mosaicism

Masuzaki, H. et al.Detection of cell free placental DNA in mate plasma
J. Med. Genet. 41, 289–292 • 2004

ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2¢,3¢-dideoxycytidine and 9¢-(2¢phosphonylmethoxyethyl) adenine

Guo, Y. et al.MRP
J. Biol • 2003

Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12

H Shimizu
Gene 310, • 2003

Critical role of arginine-482 in methotrexate transport

Mitomo, H. et al. A functional study on polymorphism of the A ABCG12
Biochem. J. 373, 767–774 • 2003

Similar Papers

Loading similar papers…