A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

  title={A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence},
  author={Vineet D. Menachery and Boyd L. Yount and Kari Debbink and Sudhakar S. Agnihothram and Lisa E. Gralinski and Jessica A. Plante and Rachel L. Graham and Trevor D. Scobey and Xingyi Ge and Eric Donaldson and Scott H. Randell and Antonio Lanzavecchia and Wayne A. Marasco and Zh{\`e}ngl{\`i} Sh{\'i} and Ralph S. Baric},
  journal={Nature Medicine},
  pages={1508 - 1513}
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations. Using the SARS-CoV reverse genetics system, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a… 

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  • B. YountK. Curtis R. Baric
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). Using a panel of contiguous cDNAs that span the entire genome, we have