A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.

  title={A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.},
  author={Rong Hu and Wei Liu and Hui Li and Li Yang and Chao Chen and Zhu-Ying Xia and Li-juan Guo and Hui Xie and Hou-de Zhou and Xian-ping Wu and Xiang-Hang Luo},
  journal={The Journal of biological chemistry},
  volume={286 14},
Our recent study showed that miR-2861 promotes osteoblast differentiation by targeting histone deacetylase 5, resulting in increased runt-related transcription factor 2 (Runx2) protein production. Here we identified another new microRNA (miRNA) (miR-3960) that played a regulatory role in osteoblast differentiation through a regulatory feedback loop with miR-2861. miR-3960 and miR-2861 were found clustered at the same loci. miR-3960 was transcribed during bone morphogenic protein 2 (BMP2… CONTINUE READING


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