A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control.

@article{AngusHill2001ARZ,
  title={A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control.},
  author={Melinda L. Angus-Hill and Alisha Schlichter and Douglas Roberts and Hediye Erdjument-Bromage and Paul Tempst and Bradley R. Cairns},
  journal={Molecular cell},
  year={2001},
  volume={7 4},
  pages={741-51}
}
Chromatin remodeling complexes perform central roles in transcriptional regulation. Here, we identify Rsc3 and Rsc30 as novel components of the essential yeast remodeler RSC complex. Rsc3 and Rsc30 function requires their zinc cluster domain, a known site-specific DNA binding motif. RSC3 is essential, and rsc3 Ts- mutants display a G2/M cell cycle arrest involving the spindle assembly checkpoint pathway, whereas rsc30Delta mutants are viable and osmosensitive. Rsc3 and Rsc30 interact… CONTINUE READING
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