A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome

  title={A Rough Set-Based Model of HIV-1 Reverse Transcriptase Resistome},
  author={Marcin Kierczak and Krzysztof Ginalski and Michał Dramiński and Jacek Koronacki and Witold R. Rudnicki and Jan Komorowski},
  booktitle={Bioinformatics and biology insights},
Reverse transcriptase (RT) is a viral enzyme crucial for HIV-1 replication. Currently, 12 drugs are targeted against the RT. The low fidelity of the RT-mediated transcription leads to the quick accumulation of drug-resistance mutations. The sequence-resistance relationship remains only partially understood. Using publicly available data collected from over 15 years of HIV proteome research, we have created a general and predictive rule-based model of HIV-1 resistance to eight RT inhibitors. Our… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

HIV Resistance Database [website

  • V Calvez, B Masquelier, coords
  • Available at: http: //hivfrenchre si stance. org…
  • 2009

Similar Papers

Loading similar papers…