A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling

@article{Cliffe2003ARO,
  title={A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling},
  author={Adam Cliffe and Fumihiko Hamada and Mariann Bienz},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={960-966}
}
Wnt signaling causes changes in gene transcription that are pivotal for normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin, or Drosophila Armadillo. In the absence of Wnt ligand, beta-catenin is phosphorylated by the Axin complex, which earmarks it for rapid degradation by the ubiquitin system. Axin acts as a scaffold in this complex, to assemble beta-catenin substrate and kinases (casein kinase I [CKI] and glycogen synthase kinase 3 beta [GSK3]). The… CONTINUE READING
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Wnt signal transduction: kinase phospholipid binding motif that is conserved in the DIX

  • Y. Ding, T. Dale
  • 2002

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