A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.

@article{GomezLopez2017ARF,
  title={A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.},
  author={Nardhy Gomez-Lopez and Roberto Romero and Yi Xu and Olesya Plazyo and Ronald Unkel and Yaozhu Leng and Nandor Gabor Than and Tinnakorn Chaiworapongsa and Bogdan Panaitescu and Zhong Dong and Adi L Tarca and Vikki M Abrahams and Lami Yeo and Sonia S. Hassan},
  journal={Reproductive sciences},
  year={2017},
  volume={24 10},
  pages={
          1382-1401
        }
}
Inflammasomes are cytosolic multiprotein complexes that orchestrate inflammation in response to pathogens and endogenous danger signals. Herein, we determined whether the chorioamniotic membranes from women in spontaneous preterm labor with acute histologic chorioamnionitis (1) express major inflammasome components; (2) express caspase (CASP)-1 and CASP-4 as well as their active forms; (3) exhibit apoptosis-associated speck-like protein containing a CARD (ASC)/CASP-1 complex formation; and (4… CONTINUE READING
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