A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response

@article{Zhang2006ARF,
  title={A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response},
  author={Dong Zhang and Kathrin Zaugg and Tak W Mak and Stephen J Elledge},
  journal={Cell},
  year={2006},
  volume={126},
  pages={529-542}
}
The Chk2-p53-PUMA pathway is a major regulator of DNA-damage-induced apoptosis in response to double-strand breaks in vivo. Through analysis of 53BP1 complexes we have discovered a new ubiquitin protease, USP28, which regulates this pathway. Using a human cell line that faithfully recapitulated the Chk2-p53-PUMA pathway, we show that USP28 is required to stabilize Chk2 and 53BP1 in response to DNA damage. In this cell line, both USP28 and Chk2 are required for DNA-damage-induced apoptosis, and… CONTINUE READING
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