A Role for the Cleaved Cytoplasmic Domain of E-cadherin in the Nucleus*S⃞

@article{Ferber2008ARF,
  title={A Role for the Cleaved Cytoplasmic Domain of E-cadherin in the Nucleus*S⃞},
  author={Emma C. Ferber and Mihoko Kajita and Anthony Wadlow and Lara Tobiansky and C. Niessen and Hiroyoshi Ariga and Juliet M. Daniel and Yasuyuki Fujita},
  journal={The Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={12691 - 12700}
}
Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood. E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by gamma-secretase. This cleavage releases a fragment of E-cadherin, E-cadherin C-terminal fragment 2 (E-cad/CTF2), into the cytosol. Here, we study the fate and function of this fragment. First, we show that coexpression of the cadherin-binding protein, p120… CONTINUE READING