A Role for the-Catenin / T-Cell Factor Signaling Cascade in Vascular Remodeling

  title={A Role for the-Catenin / T-Cell Factor Signaling Cascade in Vascular Remodeling},
  author={Xiaohong Wang and Yan Xiao and Yongshan Mou and Ying Zhao and W. Matthijs Blankesteijn and Jennifer Hall},
-Catenin and T cell factor (Tcf) are distal components of the highly conserved Wnt pathway that govern cell fate and proliferation in lower organisms. Thus, we hypothesized that the regulation of -catenin and Tcf played a critical role in vascular remodeling. The first objective was to define -catenin expression in vascular smooth muscle cells (VSMCs) after balloon injury. Indeed, -catenin mRNA and protein were significantly elevated 7 days after balloon injury in the rat carotid artery. We… CONTINUE READING


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Catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction

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