A Role for tRNA Modifications in Genome Structure and Codon Usage

@article{Novoa2012ARF,
  title={A Role for tRNA Modifications in Genome Structure and Codon Usage},
  author={Eva Maria Novoa and Mariana Pavon-Eternod and Tao Pan and Llu{\'i}s Ribas de Pouplana},
  journal={Cell},
  year={2012},
  volume={149},
  pages={202-213}
}
Transfer RNA (tRNA) gene content is a differentiating feature of genomes that contributes to the efficiency of the translational apparatus, but the principles shaping tRNA gene copy number and codon composition are poorly understood. Here, we report that the emergence of two specific tRNA modifications shaped the structure and composition of all extant genomes. Through the analysis of more than 500 genomes, we identify two kingdom-specific tRNA modifications as major contributors that separated… 
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