A Role for tRNA Modifications in Genome Structure and Codon Usage

Abstract

Transfer RNA (tRNA) gene content is a differentiating feature of genomes that contributes to the efficiency of the translational apparatus, but the principles shaping tRNA gene copy number and codon composition are poorly understood. Here, we report that the emergence of two specific tRNA modifications shaped the structure and composition of all extant… (More)
DOI: 10.1016/j.cell.2012.01.050

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