A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

@inproceedings{Garcia2010ARF,
  title={A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome},
  author={O. Pavlov Garcia and Maria A Garc{\'i}a Torres and Pablo R Helguera and Pinar Koksal Coskun and Jorge A. Busciglio},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Down's syndrome (DS) is the most common genetic cause of mental retardation. Reduced number and aberrant architecture of dendritic spines are common features of DS neuropathology. However, the mechanisms involved in DS spine alterations are not known. In addition to a relevant role in synapse formation and maintenance, astrocytes can regulate spine dynamics by releasing soluble factors or by physical contact with neurons. We have previously shown impaired mitochondrial function in DS… CONTINUE READING

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