A Role for Small RNAs in DNA Double-Strand Break Repair

@article{Wei2012ARF,
  title={A Role for Small RNAs in DNA Double-Strand Break Repair},
  author={Wei Wei and Zhaoqing Ba and Min Gao and Yang Wu and Yanting Ma and Simon Amiard and Charles I White and Jannie Michaela Rendtlew Danielsen and Yun-Gui Yang and Yijun Qi},
  journal={Cell},
  year={2012},
  volume={149},
  pages={101-112}
}
Eukaryotes have evolved complex mechanisms to repair DNA double-strand breaks (DSBs) through coordinated actions of protein sensors, transducers, and effectors. Here we show that ∼21-nucleotide small RNAs are produced from the sequences in the vicinity of DSB sites in Arabidopsis and in human cells. We refer to these as diRNAs for DSB-induced small RNAs. In Arabidopsis, the biogenesis of diRNAs requires the PI3 kinase ATR, RNA polymerase IV (Pol IV), and Dicer-like proteins. Mutations in these… CONTINUE READING
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