A Role for SSeCKS, a Major Protein Kinase C Substrate with Tumour Suppressor Activity, in Cytoskeletal Architecture, Formation of Migratory Processes, and Cell Migration During Embryogenesis

@article{Gelman2000ARF,
  title={A Role for SSeCKS, a Major Protein Kinase C Substrate with Tumour Suppressor Activity, in Cytoskeletal Architecture, Formation of Migratory Processes, and Cell Migration During Embryogenesis},
  author={Irwin H. Gelman and Eugene Tombler and Jes{\'u}s Segovia Vargas},
  journal={The Histochemical Journal},
  year={2000},
  volume={32},
  pages={13-26}
}
SSeCKS is a major protein kinase C substrate which has tumour suppressor activity in models of src- and ras-induced oncogenic transformation. The mitogenic regulatory activity of SSeCKS is likely manifested by its ability to bind key signalling proteins such as protein kinases C and A and calmodulin, and to control actin-based cytoskeletal architecture. Rat SSeCKS shares extensive homology with human Gravin, an autoantigen in myasthenia gravis that encodes kinase scaffolding functions and whose… CONTINUE READING

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