A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export

@article{Kehlenbach1999ARF,
  title={A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore  Complex in a Terminal Step of Nuclear Export },
  author={Ralph H Kehlenbach and Achim Dickmanns and Angelika Kehlenbach and Tinglu Guan and Larry Gerace},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={145},
  pages={645 - 657}
}
We recently developed an assay in which nuclear export of the shuttling transcription factor NFAT (nuclear factor of activated T cells) can be reconstituted in permeabilized cells with the GTPase Ran and the nuclear export receptor CRM1. We have now used this assay to identify another export factor. After preincubation of permeabilized cells with a Ran mutant that cannot hydrolyze GTP (RanQ69L), cytosol supports NFAT export, but CRM1 and Ran alone do not. The RanQ69L preincubation leads to… CONTINUE READING
66 Extracted Citations
48 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 66 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 48 references

Major binding sites

  • S. Tugendreich, D. Forbes
  • 1998
Highly Influential
16 Excerpts

nucleopore regions during their nuclear import

  • N. Panté, R. Bastos, I. McMorrow, B. Burke, U. Aebi
  • Interactions
  • 1994
Highly Influential
4 Excerpts

nuclear filament protein Tpr

  • C. M. Snow, A. Senior, L. Gerace
  • J. Cell Biol
  • 1987
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…