A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish

@article{Houwing2007ARF,
  title={A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish},
  author={Saskia Houwing and Leonie M Kamminga and Eugene Berezikov and Daniela Cronembold and Ang{\'e}lique Girard and Hans van den Elst and Dmitri V. Filippov and Heiko Blaser and Erez Raz and Cecilia B Moens and Ronald H. A. Plasterk and Gregory J Hannon and Bruce W Draper and Ren{\'e} F Ketting},
  journal={Cell},
  year={2007},
  volume={129},
  pages={69-82}
}
Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates, is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is expressed in both the male and the female gonad and is a component of a germline-specifying structure called nuage. Loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development. In animals that have reduced Ziwi function, germ cells are maintained but display abnormal… CONTINUE READING
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